The DiMarzio ISCV2 Evolution Single Coil Pickup is specifically designed for use with DiMarzio Evolution Neck and Bridge models in a wiring configuration made popular by Steve Vai.
When the 5-way switch is in the 1 or 5 position, you hear the neck or bridge humbucker. When played in the 2 or 4 position, the middle single-coil combines in parallel with one coil of either humbucker and produces a distinctive tone with hum cancellation. The middle (3) position gives a true single coil sound which is not hum canceling and is not like an Evolution humbucker.
A schematic of this wiring configuration is included with the ISCV2